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Quincke's edema and anaphylactic shock with insulin administration require prompt response and rapid relief of these conditions. The drugs of choice are glucocorticosteroids.
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With the development of amoxil, it may be necessary to carry out resuscitation measures - in particular, tracheal intubation and connecting the patient to an artificial respiration apparatus to ensure the act of breathing during suffocation. Kovtonyuk Oksana Vladimirovna, medical commentator, surgeon, medical consultant.
Insulin is vital for a large group of people. Without it, a person with diabetes can die, because this is the only method of Amoxicillin treatment that has no analogues yet. At the same time, in 20% of people, the use of this drug causes allergic reactions of varying degrees of complexity. Most often, young girls are subject to this, less often - older people over 60 years old.
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Depending on the degree of purification and impurities, there are several options for insulin - human, recombinant, bovine and porcine. Most of the reactions occur on the drug itself, much less on the substances contained in its composition, such as zinc, protamine. Human is the least allergenic, while the largest number of negative effects was recorded when using bovine. In recent years, highly purified insulins have been used, which contain no more than 10 μg/g of proinsulin, which has improved the situation with insulin allergy in general.
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Hypersensitivity is caused by antibodies of various classes. Immunoglobulins E are responsible for anaphylaxis, IgG for local allergic reactions, and zinc for delayed-type allergy, which will be discussed in more detail below.
Local reactions can also be due to misuse, such as trauma to the skin with a thick needle or a poorly chosen injection site. Immediate - occurs 15-30 minutes after insulin administration in the form of severe itching or changes in the skin: dermatitis, urticaria or redness at the injection site. Slow - it may take a day or more before symptoms appear.
Slowdown is of three types: Local - only the injection site is affected. Systemic - other areas are affected. Combined - both the injection site and other parts of the body are affected. Usually, an allergy is expressed only in a change in the skin, but stronger and more dangerous consequences are possible, such as anaphylactic shock.
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In a small group of people, taking the medication provokes a generalized reaction, characterized by such unpleasant symptoms as: Slight increase in temperature. Weakness. Fatigue. Indigestion. Joint pain. Spasm of the bronchi. Enlarged lymph nodes.
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Very high temperature. Necrosis of subcutaneous tissues. Edema of lung tissue. Also, the medication can cause anaphylactic shock and angioedema - an increase in the limb, part and or all of the face. They are the most dangerous and pose a real threat to life and health, and their neutralization requires highly qualified and fast medical assistance.
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In rare cases, serious reactions such as: The presence of an allergy to insulin is determined by an immunologist or an allergist based on an analysis of amoxil and anamnesis. For a more accurate diagnosis, you will also need:
Donate blood (general analysis, for sugar levels and for determining the level of amoxil), Exclude skin and blood diseases, infections, skin itching as a result of liver failure. Make small dose samples of all types. The reaction is determined an hour after the procedure by the severity and size of the resulting papule. Treatment is prescribed only by a doctor, depending on the type of allergy.
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Mild symptoms resolve without intervention within 40-60 minutes. If the manifestations persist for a long time and become worse each time, then it is necessary to start taking antihistamine drugs, such as diphenhydramine and suprastin.